Salmonella choleraesuis live vaccine for swine, freeze-dried for oral and parenteral administration after reconstitution.
1 dose (1 ml reconstituted vaccine) contains:
a minimum of 1 x 108 cfu of a genetically stabile, double attenuated Salmonella choleraesuis mutant Swine serum protein max. 1.0 %
Active immunization of swine against Salmonella choleraesuis infection.
Animals with salmonellosis
A slight increase in internal body temperature (approx. 1-2 °C) may be seen. Interactions Chemotherapeutic drugs should be withdrawn for five days before and five days after immunization with SALMOPORC SCS. If such therapy is absolutely necessary then the animals should be immunized again afterwards. Concomitant administration of SALMOPORC SCS and live swine erysipelas vaccine at different injection sites does not inhibit the development of immunity.
Interactions with other vaccines have not been investigated.
Administration and Dosage
The freeze-dried powder in a vial is reconstituted with the diluent (1 ml = 1 dose).
One single oral dose when animals are three weeks old.
One i.m. or oral dose at the time of transfer to fattening or rearing facilities.
Two doses at 5 and 2 weeks a.p., either s.c. or i.m.
Booster dose during subsequent pregnancies: 1 dose 2 weeks a.p., either s.c. or i.m.
Revaccination with a single dose at 6-month intervals, s.c. or i.m.
Oral administration is made as follows:
Feeding and drinking machines are turned off and food and water with drawn for one meal (or half a day)
Animal to feeder space ratio 1:1 on day of administration
The reconstituted vaccine is introduced into a 1 % skimmed milk powder-drinking water suspension (or 10% skimmed milk-drinking water suspension) at a concentration of 1 dose per~ 1,000 ml suspension and mixed
The pigs are given this suspension to drink - approx 1 litre per animal
Once the pigs have fully consumed the immunization drink they are once again given access to feed and water.
Please note the following
The fluid drunk by the animals and the containers used for dilution of the vaccine must be free of all traces of disinfectants or detergents.
Original vaccine vials and all vessels used in the course of vaccination must be disinfected after use (using disinfectants at their usual concentrations - except quaternary ammonium bases).
Reconstituted live vaccine must be used within 4 hours.
The attenuated vaccine strain can be distinguished from wild strains of Salmonella choleraesuis using the SALMOPORC SCS diagnostic kit.
Vial of 10 doses, plus 10 ml diluent
Vial of 50 doses, plus 50 ml diluent
Mode of action
The existence of a protective effect was demonstrated just 3 days after oral immunization of piglets with SALMOPORC SCS (Schöll and Grünert 1980). Stabile immunity was achieved approx. 14 days after immunization and persists following second oral or parenteral immunization of animals aged approx. 100 days (weight ca 35 kg live mass) until the animals are ready for slaughter. Continual usage of SALMOPORC SCS within the framework of a complex anti-salmonella programme effectively eliminates clinical manifestations of salmonellosis in swine in the short term and reduces the incidence of latent salmonellosis in the long term. It thus supports efforts to eradicate the disease from herds. Information on the concomitant use of SALMOPORC SCS and live swine erysipelas vaccine is given in the papers of Urbaneck and Koban (1988) and Danner (1991).
The causal agents of salmonella infections in swine are the adapted serotype Salmonella choleraesuis and non adapted serotypes, especially Salmonella typhimurium. They are important in swine for two reasons, firstly as the cause of severe diseases and losses of animals, and secondly because of infection of humans due to consumption of meat containing salmonella from animals which in most cases show no symptoms of infection.
SALMOPORC SCS is a live Salmonella choleraesuis vaccine for pigs of all ages. The vaccine is based on an avirulent immunogenic mutant S.choleraesuis strain that differs from wild strain through 2 attenuation markers. these attenuation markers are purine auxotrophy and the R-form.
TESTS FOR SAFETY
The degree to which SALMOPORC SCS is tolerated was established with pigs of different ages. SALMOPORC SCS was well tolerated up to a tenfold dose used for vaccination. The results were checked in a number of field studies and in a recent survey of 8 veterinary practices for their relevance to practical use.
Here too, SALMOPORC SCS administered by oral, subcutaneous, or intramuscularly route was found to be tolerated without exception by piglets, sows and fattening swine housed under very different conditions. Persistence of the vaccine strain in the body is limited:
The vaccine strain has been shown to persist in the body for up to 3 weeks after vaccination.
The organism has been demonstrated in rectal swabs for up to 11 days after vaccination.
The efficacy of SALMOPORC SCS was confirmed in extensive laboratory and field trials.
SALMOPORC SCS confers adequate immunity against massive experimental challenge and a high level of protection under practice conditions.
A positive protective effect is seen in piglets only three days after oral administration. This is attributable to non-specific resistance mechanisms as a result of macrophage activity. An adequate level of immunity is seen 14 days after oral or parenteral administration. This is maintained until the animals are ready for slaughter at 110-120 kg provided a booster dose is given when animals weigh 35 kg (aged ca. 3-3.5 months).
IMMUNIZATION SCHEDULE FOR SALMOPORC SCS
An important part of the vaccination regimen is the immunization of breeders. This enables effective, protecttion of young piglets via the colostrum. The passive oral immunization of neonates protects them during their first days of life when their own immune system is not yet able to react sufficiently to infection. This passive immunity is rendered in active once the piglets being three weeks old get single oral immunization.
Herd immunized with 1 dose of SALMOPORC SCS
Sows: Young sows: 2 x 1 dose 5 and 2 weeks a.p. s.c. (i.m.). Adult sows: 1 dose 2 weeks a.p. s.c. (i.m.)
Piglets aged 21 days on: 1 dose oral
Young pigs upon transfer to breeding or fattening facilities
Breeding boars: 1 dose every 6 months, s.c. (i.m.)
RESULTS OF FELD TRIALS
The following results drawn from field trials are by way of summary:
Use of the live vaccine has enabled abrogation of clinical symptoms of salmonellosis in pigs.
The number of animals lost in infected herds was radically reduced.
The number of samples tested positive for salmonellosis was reduced to a constant level or isolated instances, thus allowing the herd to be freed of infection.
UrbanecK D. und 1. Koban; Mh. Vet Med. 43 (1988), p. 705-710
Meyer u. Mitarbeiter Mh. Vet Med, 45 (1990), p. 403-406
Danner, Tierärztliche Umschau 11/1991, p. 638-648
Hartung, M., Dtsch. tierärztl. Wschr. 100 (1993) Heft 7, p. 249-300
|Place of Origin:||Germany|